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Products Sodium-Iodide Symporter, FP5
| Catalogue number: | SMC-391D |
| Reactivities: | Human, Mouse, Rat |
| Hosts: | Mouse |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug |
| Clone: | FP5 |
| Accession: | NP_000444.1 |
| Gene: | 6528 |
| Swiss prot: | Q92911 |
| Dilutions: | 1:1000 (WB) |
| Form: | Protein G purified |
| Storage buffer: | PBS pH7.4, 50% glycerol |
| Concentration: | 1mg/mL |
| Isotype: | IgG1 Kappa |
| Shipping temp: | Blue Ice or 4 |
| Storage temp: | -20 |
| Research area: | Ion Channels |
| Certificate of analysis: | 1 ug/mL of SMC-391 was sufficient for detection of hNIS in 20 ug of transfected COS-7 cell membrane lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Scientific background: | The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells (1, 2). This is important step in the process of iodide organificaton and the formation of triiodothyronine and |
| Alternative names: | NIS, SLC5A5, solute carrier family 5, Na (+)I(-) cotransporter |
| References: | 1. Dai G., Levy O., Carrasco N. (1996) Nature. 379(6564): 458-460. 2. Snabik P.A., et al. (1997) Endocrin. 138(8): 3555-3558. 3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104(51): 20250-20255. |
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