Catalogue number: |
SMC-185C |
Reactivities: |
Human |
Hosts: |
Mouse |
Applications: |
ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot |
Size: |
25ug |
Clone: |
EP190B |
Accession: |
NP_001421.4 |
Gene: |
2034 |
Swiss prot: |
Q99814 |
Dilutions: |
1:100-1:500 (WB) |
Form: |
Protein G Purified |
Storage buffer: |
PBS pH7.4, 50% glycerol |
Concentration: |
1mg/mL |
Isotype: |
IgG1 |
Shipping temp: |
Blue Ice or 4 |
Storage temp: |
-20 |
Research area: |
Oxidative Stress/Cell Signaling |
Certificate of analysis: |
1 ug/mL of SMC-185 was sufficient for detection of HIF2(A) in 20ug of CoCl2-induced Hela cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
Scientific background: |
Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to
hypoxia (1). HIF2-Alpha is involved in catecholamine
homeostasis, vascular remodeling, physiological
angiogenesis and adipogenesis. It is overe |
Alternative names: |
ECYT4, EPAS1, HIF2alpha, HIF1 Alpha like factor, HLF, Hypoxia inducible factor 2 alpha, MOP2, PASD2 |
References: |
1. Kim W.Y., et al. (2009) J Clin Invest. 119(8): 2160-2170. 2. Favier J., Lapointe S., Maliba R. and Sirois M.G.
(2007) BMC Cancer. 7:139.
3. Imtiyaz H.Z., et al. (2010) J Clin Invest. 120(8):
2699-2714. |