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Products Nav1.1, S74-71
| Catalogue number: | SMC-376D |
| Reactivities: | Human, Mouse, Rat |
| Hosts: | Mouse |
| Applications: | Immunohistochemistry, Immunoprecipitation, Western Blot |
| Size: | 100ug |
| Clone: | S74-71 |
| Accession: | NP_061203.2 |
| Gene: | 20265 |
| Swiss prot: | Q62206 |
| Dilutions: | 1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF) |
| Form: | Protein G Purified |
| Storage buffer: | PBS pH7.4, 50% glycerol |
| Concentration: | 1mg/mL |
| Isotype: | 1gG1 |
| Shipping temp: | Blue Ice or 4 |
| Storage temp: | -20 |
| Research area: | Ion Channels |
| Certificate of analysis: | 1 ug/mL of SMC-376 was sufficient for detection of Nav1.1 in 20ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Scientific background: | Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies sho |
| Alternative names: | FEB3, Scn1a, GEFSP2, HBSCI, SCN1 |
| References: | 1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Kalume F., et al. (2007) J Neurosci. 27(41): 11065- 11074. |
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