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Products MDC1, P2B11
| Catalogue number: | SMC-197D |
| Reactivities: | Human, Mouse, Bovine |
| Hosts: | Mouse |
| Applications: | Western Blot |
| Size: | 100ug |
| Clone: | P2B11 |
| Accession: | NP_001010833.2 |
| Gene: | 240087 |
| Swiss prot: | Q5PSV9 |
| Form: | Protein G Purified |
| Storage buffer: | PBS pH7.4, 50% glycerol |
| Concentration: | 1mg/mL |
| Isotype: | IgG1 |
| Shipping temp: | Blue Ice or 4 |
| Storage temp: | -20 |
| Research area: | Oxidative Stress |
| Certificate of analysis: | 0.5 ug/ml of SMC-197 was sufficient for detection of MDC1 in 10ug of HeLa cell lysate by ECL immunoblot analysis. |
| Scientific background: | MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal trans |
| Alternative names: | Nuclear factor with BRCT domains1, mediator of DNA damage checkpoint 1 |
| References: | 1. Lou Z., et al. (2004) J Biol Chem. 279(45): 46359-46362. 2. Luo K., Yuan J, Lou Z. (2011) J Biol Chem. 286(32): 28192-28199. 3. Strauss C., Halevy T., Macarov M., Argaman L., and Goldbery M. (2011) DNA Repair (Amst.). 10(8): 806-814. 4. Wilson K.A., et |
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