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Products FIH, FIH162C
| Catalogue number: | SMC-182D |
| Reactivities: | Human |
| Hosts: | Mouse |
| Applications: | Western Blot |
| Size: | 100ug |
| Clone: | FIH 162c |
| Dilutions: | 10ug/mL( WB) |
| Form: | Protein G purified |
| Storage buffer: | PBS pH7.4, 50% glycerol |
| Concentration: | 1mg/mL |
| Isotype: | IgG1 |
| Shipping temp: | Blue Ice or 4 |
| Storage temp: | -20 |
| Research area: | Oxidative Stress/ Cell Signaling |
| Certificate of analysis: | 1ug/mL of SMC-182 was sufficient for detection of FIH in 20ug of Hela lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
| Scientific background: | FIH, Factor inhibiting HIF1 (hypoxia-inducible factor), is an asparaginyl hydroxylase. FIH in conjunction with VHL represses HIF-1 transcriptional activity by disrupting the interaction of HIF-1 with the transcriptional coactivators CBP/p300, and by recru |
| References: | 1. Stolze I.P., et al. (2004) J Bio Chem. 42719-42725. 2. Soilleux E.J., et al. (2005) Histopathology 47:602- 610. 3. Moon H., Han S., Park H., Choe J. (2010) Mol Cells. 29(5): 471-474. 4. Kroeze S.G., et al. (2010) Eur J Cancer. Epub. |
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