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Products DNMT3L, S117-9
| Catalogue number: | SMC-341D |
| Reactivities: | Human |
| Hosts: | Mouse |
| Applications: | Immunocytochemistry, Immunoprecipitation, Western Blot |
| Size: | 100ug |
| Clone: | S117-9 |
| Accession: | NP_037501.2 |
| Gene: | 29947 |
| Swiss prot: | Q9UJW3 |
| Dilutions: | 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF) |
| Form: | Protein G Purified |
| Storage buffer: | PBS pH7.4, 50% glycerol |
| Concentration: | 1mg/mL |
| Isotype: | IgG1 |
| Shipping temp: | Blue Ice or 4 |
| Storage temp: | -20 |
| Research area: | Epigenetics |
| Certificate of analysis: | 1ug/mL of SMC-341 was sufficient for detection of DNMT3L in 10ug of COS cell transiently transfected with Flag-tagged DNMT3L lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
| Scientific background: | Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic D |
| Alternative names: | DNA (cytosine-5-)-methyltransferease 3-like, MGC1090 |
| References: | 1. Bestor T., et al.(1988) J.Mol. Biol. 203: 971-983. 2. Yen R.W., Vertino P.M., Nelkin B.D. et al. (1992) Nucl. Acids Res. 20: 2287-2291. 3. Xie S. et al. (1999) Gene 236: 87-95. 4. Okano M., Bell D.W., Haber D.A. and Li E. (1999) Cell 99: 247-257. 5. Re |
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