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Products DNMT1
| Catalogue number: | SMC-201D |
| Reactivities: | Human, Mouse |
| Hosts: | Mouse |
| Applications: | Immunohistochemistry, Immunoprecipitation, Western Blot |
| Size: | 100ug |
| Accession: | NP_001370 |
| Gene: | 1786 |
| Swiss prot: | P26358 |
| Dilutions: | 2-4ug/mL (WB), 1-2ug/mL (IHC) |
| Form: | Protein G Purified |
| Storage buffer: | PBS, 0.05% BSA |
| Concentration: | 1mg/mL |
| Isotype: | IgG1kappa |
| Shipping temp: | Blue Ice or 4 |
| Storage temp: | -20 |
| Research area: | Cell signaling, organelle marker |
| Certificate of analysis: | 2 ug/mL of SMC-201 was sufficient for detection of Dnmt1 in 10ug of mouse ES cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Scientific background: | Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic D |
| Alternative names: | DNA Mtase, DNMT, MCMT, DNA methyltransferase 1 |
| References: | 1. Bestor T., et al.(1988) J.Mol. Biol. 203: 971-983. 2. Yen R.W., Vertino P.M., Nelkin B.D. et al. (1992) Nucl. Acids Res. 20: 2287-2291. 3. Xie S. et al. (1999) Gene 236: 87-95. 4. Okano M., Bell D.W., Haber D.A. and Li E. (1999) Cell 99: 247-257. 5. Re |
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