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Products BK Beta4, S18A-3
| Catalogue number: | SMC-384D |
| Reactivities: | Human, Mouse |
| Hosts: | Mouse |
| Applications: | Immunohistochemistry, Immunoprecipitation, Western Blot |
| Size: | 100ug |
| Clone: | S18A-3 |
| Dilutions: | 1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF) |
| Form: | Protein G Purified |
| Storage buffer: | PBS pH7.4, 50% glycerol |
| Concentration: | 1mg/mL |
| Isotype: | IgG2A |
| Shipping temp: | Blue Ice or 4 |
| Storage temp: | -20 |
| Research area: | Ion Channels |
| Certificate of analysis: | 1 ug/mL of SMC-384 was sufficient for detection of BK Channel beta4 in 10ug of COS-1 cells transiently transfected with KBeta2 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Scientific background: | BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological disea |
| References: | 1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA 2. www.iochannels.org 3. Wulf-Johansson H., et al. (2009) Brain Res. 1292: 1-13. 4. Lee U.S., and Cui J. (2009) J Physiol. 587(7): 1481-1489. |
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