Polyclonal Anti-Vitronectin/VTN

Rabbit IgG polyclonal antibody for Vitronectin (VTN) detection. Tested with WB in Human;Mouse;Rat. \n\n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1799

Size

100ug/vial

Applications

WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

VTN

References

1. Fink, T. M., Jenne, D. E., Lichter, P.The human vitronectin (complement S-protein) gene maps to the \ncentromeric region of 17q.Hum. Genet. 88: 569-572, 1992.\n2. Kubota, K., Katayama, S., Matsuda, M., Hayashi, M.Three types of vitronectin in human blood.Cell \nStruct. Funct. 13: 123-128, 1988.\n3. Preissner, K. T., Heimburger, N., Anders, E., Muller-Berghaus, G.Physicochemical, immunological and \nfunctional comparison of human S-protein and vitronectin: evidence for the identity of both plasma \nproteins.Biochem. Biophys. Res. Commun. 134: 951-956, 1986.

Swiss Prot

P04004

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of \nhuman Vitronectin, identical to the related rat and mouse sequences.

Scientific Background

Vitronectin (VTN)also known as complement S-protein, serum spreading factor and somatomedin B is a \nprotein that in humans is encoded by the VTN gene. The protein encoded by this gene is a member of \nthe pexin family. Vitronectin is an abundant glycoprotein found in serum and the extracellular matrix and \npromotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic \ncomplement pathway, and binds to several serpin serine protease inhibitors. Vitronectin is a 75 kDa \nglycoprotein, consisting of 459 amino acid residues. By use of high resolution fluorescence in situ \nhybridization (FISH), Fink et al. (1992) mapped the VTN gene to 17q11. The localization was confirmed \nby cohybridization with a centromere-specific alphoid probe. About one-third of the protein's molecular \nmass is composed of carbohydrates. It is a secreted protein and exists in either a single chain form or a \nclipped, two chain form held together by a disulfide bond. Vitronectin has been speculated to be involved \nin hemostasis and tumor malignancy.