

Supplier:
Boster ImmunoleaderCat no: RP1000
Polyclonal Anti-mouse TNF alpha
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SPECIFICATIONS
Price
240.00 USD
Catalog Number
RP1000
Size
100ug/vial
Applications
BNI, ELISA, IHC, IP, WB
Reactivities
Mouse
Conjugates
Unconj, Agarose, AP, Biotin, Gold, HRP, BE, GE, YE, OE, RE, FRE, NIR, ONFC
Form
Lyophilized
Format
Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Gene Id
TNF
References
1. Shirai, T., Yamaguchi, H., Ito, H., Todd, C. W., Wallace, R. B.Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.Nature 313: 803-806, 1985.\n2. Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., Goeddel, D. V.Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.Nature 312: 724-729, 1984.
Swiss Prot
P06804
Storage Temp
\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n
Additional Info
E. coli-derived mouse TNF alpha recombinant protein (Position: L80-L235).
Scientific Background
TNF(A)(Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
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