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Polyclonal Anti-TSC2

Cat no: PA2175

Polyclonal Anti-TSC2

Rabbit IgG polyclonal antibody for Tuberin (TSC2) detection. Tested with WB in Human;Mouse;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2175

Size

100?g/vial

Applications

WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

TSC2

References

1. Chu-Shore, C. J., Major, P., Montenegro, M., Thiele, E. Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex. Neurology 72: 1165-1169, 2009. \n2. Jansen, F. E., Braams, O., Vincken, K. L., Algra, A., Anbeek, P., Jennekens-Schinkel, A., Halley, D., Zonnenberg, B. A., van den Ouweland, A., van Huffelen, A. C., van Nieuwenhuizen, O., Nellist, M. Overlapping neurologic and cognitive phenotypes in patients with TSC1 or TSC2 mutations. Neurology 70: 908-915, 2008. \n

Swiss Prot

P49815

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human TSC2, identical to the related mouse and rat sequences.

Scientific Background

Tuberous sclerosis 2 protein, also known as TSC2 or Tuberin is a protein that is in humans. The chromosomal location of this gene is 16p13.3. Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. This gene involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. It stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro.

Applications

WB

Reactivities

Hum

More info

Applications

ELISA, WB

Reactivities

Hum

More info

Applications

ELISA, IHC, WB

Reactivities

Hum

More info

Applications

ELISA, WB

Reactivities

Mouse

More info

Applications

ELISA, IHC, WB

Reactivities

Rat

More info

Applications

BNI, ELISA, IHC, IP, WB

Reactivities

Mouse

Conjugates

Unconj, Agarose, AP, Biotin, Gold, HRP, BE, GE, YE, OE, RE, FRE, NIR, ONFC

More info

Applications

BNI, ELISA, IHC, IP, WB

Reactivities

Rat

More info

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