Polyclonal Anti-Troponin C1/TNNC1

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Bermingham, N., Hernandez, D., Balfour, A., Gilmour, F., Martin, J. E., Fisher, E. M. \nC. Mapping TNNC1, the gene that encodes cardiac troponin I in the human and mouse. Genomics \n30: 620-622, 1995.\n2. Hoffmann, B., Schmidt-Traub, H., Perrot, A., Osterziel, K. J., Gessner, R. First mutation in cardiac \ntroponin C, L29Q, in a patient with hypertrophic cardiomyopathy. Hum. Mutat. 17: 524 only, 2001.\n3. Landstrom, A. P., Parvatiyar, M. S., Pinto, J. R., Marquardt, M. L., Bos, J. M., Tester, D. J., Ommen, \nS. R., Potter, J. D., Ackerman, M. J.Molecular and functional characterization of novel hypertrophic \ncardiomyopathy susceptibility mutations in TNNC1-encoded troponin C. J. Molec. Cell. Cardiol. 45: \n281-288, 2008.

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

Troponin C1(TNNC1)(troponin C type 1 (slow)), also called TROPONIN C, SLOW-TWITCH SKELETAL \nMUSCLE or TNC, is a protein that in humans is encoded by the TNNC1 gene. Using a \n'monochromosomal' hybrid panel, the TNNC1 gene is mapped to chromosome 3; subsequent analysis \nof the Genebridge 4 radiation hybrid panel localized the gene to 3p in a region consistent with the \nearlier assignment. Circular dichroism measurements revealed changes in the secondary structures of \nthe TNNC1 mutants A8V, C84Y, and D145E.