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Polyclonal Anti-Troponin C1/TNNC1

Polyclonal Anti-Troponin C1/TNNC1

Cat no: PA1779

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Troponin C, slow skeletal and cardiac muscles (TNNC1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Catalogue number: PA1779
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunohistochemistry, Western Blot
Size: 100ug/vial
Gene: TNNC1
Swiss prot: P63316
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: Troponin C1(TNNC1)(troponin C type 1 (slow)), also called TROPONIN C, SLOW-TWITCH SKELETAL MUSCLE or TNC, is a protein that in humans is encoded by the TNNC1 gene. Using a 'monochromosomal' hybrid panel, the TNNC1 gene is mapped to chromosome 3; subsequent analysis of the Genebridge 4 radiation hybrid panel localized the gene to 3p in a region consistent with the earlier assignment. Circular dichroism measurements revealed changes in the secondary structures of the TNNC1 mutants A8V, C84Y, and D145E.
References: 1. Bermingham, N., Hernandez, D., Balfour, A., Gilmour, F., Martin, J. E., Fisher, E. M. C. Mapping TNNC1, the gene that encodes cardiac troponin I in the human and mouse. Genomics 30: 620-622, 1995. 2. Hoffmann, B., Schmidt-Traub, H., Perrot, A., Osterziel, K. J., Gessner, R. First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy. Hum. Mutat. 17: 524 only, 2001. 3. Landstrom, A. P., Parvatiyar, M. S., Pinto, J. R., Marquardt, M. L., Bos, J. M., Tester, D. J., Ommen, S. R., Potter, J. D., Ackerman, M. J.Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C. J. Molec. Cell. Cardiol. 45: 281-288, 2008.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of human TNNC1/Troponin C1, identical to the related rat and mouse sequences .
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