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Products Polyclonal Anti-TRAF3
| Catalogue number: | PA2008 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | TRAF3 |
| Swiss prot: | Q13114 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | TRAF3 (TNF Receptor-Associated Factor 3), also called LAP1, CAP1, CRAF1 or CD40BP, is a protein that in humans is encoded by the TRAF3 gene. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. Gross (2012) mapped the TRAF3 gene to chromosome 14q32.32 based on an alignment of the TRAF3 sequence with the genomic sequence (GRCh37). Dadgostar et al. (2003) determined that the coiled-coil domain of mouse T3jam interacted with the isoleucine zipper domain of Traf3. Oganesyan et al. (2006) demonstrated that cells lacking TRAF3 are defective in type I interferon responses activated by several different Toll-like receptors. |
| References: | 1. Dadgostar, H., Doyle, S. E., Shahangian, A., Garcia, D. E., Cheng, G. T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. FEBS Lett. 553: 403-407, 2003. 2. Gross, M. B. Personal Communication. Baltimore, Md. 10/5/2012. 3. Oganesyan, G., Saha, S. K., Guo, B., He, J. Q., Shahangian, A., Zarnegar, B., Perry, A., Cheng, G. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 439: 208-211, 2006. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human TRAF3, identical to the related rat and mouse sequences. |
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