Polyclonal Anti-TNFRSF1B

Price

200.00 USD

Size

100ug/vial

Reactivities

Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Beltinger, C. P., White, P. S., Maris, J. M., Sulman, E. P., Jensen, S. J., LePaslier, D., Stallard, B. J., Goeddel, D. V., de Sauvage, F. J., Brodeur, G. M. Physical mapping and genomic structure of the human TNFR2 gene. Genomics 35: 94-100, 1996. \n2. Santee, S. M., Owen-Schaub, L. B. Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization. J. Biol. Chem. 271: 21151-21159, 1996.\n

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

TNFRSF1B (Tumor Necrosis Factor Receptor Subfamily Member 1B), also known as TNFR2 or TNFBR, is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. By linkage analysis, Santee and Owen Schaub (1996) confirmed the mapping of the TNFR2 gene to 1p36.3-p36.2. TNFBR (TNFR75) is the larger of the 2 TNF receptors. It is present on many cell types, especially those of myeloid origin, and is strongly expressed on stimulated T and B lymphocytes. Beltinger et al. (1996) noted that TNFR2 is the main TNF receptor found on circulating T cells and is the major mediator of autoregulatory apoptosis in CD8+ cells. TNFR2 may act with TNFR1 to kill nonlymphoid cells.