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Products Polyclonal Anti-TNFRSF1B
| Catalogue number: | PA1974 |
| Price: | $200.00 |
| Reactivities: | Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | TNFRSF1B |
| Swiss prot: | P25119 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | TNFRSF1B (Tumor Necrosis Factor Receptor Subfamily Member 1B), also known as TNFR2 or TNFBR, is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. By linkage analysis, Santee and Owen Schaub (1996) confirmed the mapping of the TNFR2 gene to 1p36.3-p36.2. TNFBR (TNFR75) is the larger of the 2 TNF receptors. It is present on many cell types, especially those of myeloid origin, and is strongly expressed on stimulated T and B lymphocytes. Beltinger et al. (1996) noted that TNFR2 is the main TNF receptor found on circulating T cells and is the major mediator of autoregulatory apoptosis in CD8+ cells. TNFR2 may act with TNFR1 to kill nonlymphoid cells. |
| References: | 1. Beltinger, C. P., White, P. S., Maris, J. M., Sulman, E. P., Jensen, S. J., LePaslier, D., Stallard, B. J., Goeddel, D. V., de Sauvage, F. J., Brodeur, G. M. Physical mapping and genomic structure of the human TNFR2 gene. Genomics 35: 94-100, 1996. 2. Santee, S. M., Owen-Schaub, L. B. Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization. J. Biol. Chem. 271: 21151-21159, 1996. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of mouse TNFRSF1B, different from the related rat sequence by three amino acids. |
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