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Products Polyclonal Anti-TNC
| Catalogue number: | PA2055 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | TNC |
| Swiss prot: | Q80YX1 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | TNC (Tenascin C), also known as TN or HXB, is a protein that in humans is encoded by the TNC gene. By means of Southern analysis of rodent-human somatic cell hybrids and by in situ hybridization using hexabrachion cDNA probes, Gulcher et al. (1990) localized the TNC gene to chromosome 9q32-q34. Olson and Srivastava (1996) reviewed processes involved in separation of the cardiac tube into the atria, ventricles, and outflow tract. They noted that tenascin is upregulated and NCAM is downregulated in the embryonic endocardial cushions. Gherzi et al. (1997) found that the TNC gene is subject to transcriptional control by OTX2. |
| References: | 1. Gherzi, R., Briata, P., Boncinelli, E., Ponassi, M., Querze, G., Viti, F., Corte, G., Zardi, L. The human homeodomain protein OTX2 binds to the human tenascin-C promoter and trans-represses its activity in transfected cells. DNA Cell Biol. 16: 559-567, 1997. 2. Gulcher, J. R., Alexakos, M. J., Le Beau, M. M., Lemons, R. S., Stefansson, K. Chromosomal localization of the human hexabrachion (tenascin) gene and evidence for recent reduplication within the gene. Genomics 6: 616-622, 1990. 3. Olson, E., Srivastava, D. Molecular pathways controlling heart development. Science 272: 671-676, 1996. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of mouse TNC, identical to the related rat sequence, and different from the related human sequence by two amino acids. |
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