Polyclonal Anti-TIMP4

Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 4 (TIMP4) detection. Tested with WB, ELISA in Human. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1078-1

Size

100?g/vial

Applications

ELISA, WB

Reactivities

Hum

Form

lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

TIMP4

References

1. Olson, T. M; Hirohata, S.; Ye, J.; Leco, K.; Seldin, M. F.; Apte, S. S. : Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 gene to human chromosome 3p25 and mouse chromosome 6, respectively. Genomics 51: 148-151, 1998. \n2. Bigg, H. F.; Shi, Y. E.; Liu, Y. E.; Steffensen, B.; Overall, C. M. : Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. J. Biol. Chem. 272: 15496-15500, 1997.\n

Swiss Prot

Q99727

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP4.

Scientific Background

The tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP4 gene contains 5 exons that span 6 kb of genomic DNA.The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. Expressed TIMP4 inhibits MMPs in vitro. TIMP4 gene is mapped to chromosome 3p25. TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.