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Products Polyclonal Anti-TIMP2
| Catalogue number: | PA1076 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | TIMP2 |
| Swiss prot: | P16035 |
| Form: | Liquid |
| Format: | Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | TIMP2 gen is encoded by 5 exons spanning 83 kb of genomic DNA. TIMP2 is 83 kilobase pairs (kb) long with exon-intron splicing sites located in preserved positions among the three members of the TIMP family. The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25. TIMP-2 abrogates angiogenic factor-induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition. |
| References: | 1. De Clerck, Y.; Szpirer, C.; Aly, M. S.; Cassiman, J.-J.; Eeckhout, Y.; Rousseau, G. : The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25. Genomics 14: 782-784, 1992. 2. Hammani, K.; Blakis, A.; Morsette, D.; Bowcock, A. M.; Schmutte, C.; Henriet, P.; DeClerck, Y. A. : Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene. J. Biol. Chem. 271: 25498-25505, 1996. 3. Seo, D.-W.; Li, H.; Guedez, L.; Wingfield, P. T.; Diaz, T.; Salloum, R.; Wei, B.; Stetler-Stevenson, W. G. : TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism. Cell 114: 171-180, 2003. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human TIMP-2(205-220aa RGAAPPKQEFLDIEDP), identical to the related rat and mouse sequences. |
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