Polyclonal Anti-TIMP2

Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 2 (TIMP2) detection. Tested with WB, IHC-P in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1076

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Liquid

Format

Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4.

Gene Id

TIMP2

References

1. De Clerck, Y.; Szpirer, C.; Aly, M. S.; Cassiman, J.-J.; Eeckhout, Y.; Rousseau, G. : The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25. Genomics 14: 782-784, 1992. \n2. Hammani, K.; Blakis, A.; Morsette, D.; Bowcock, A. M.; Schmutte, C.; Henriet, P.; DeClerck, Y. A. : Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene. J. Biol. Chem. 271: 25498-25505, 1996. \n3. Seo, D.-W.; Li, H.; Guedez, L.; Wingfield, P. T.; Diaz, T.; Salloum, R.; Wei, B.; Stetler-Stevenson, W. G. : TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism. Cell 114: 171-180, 2003.

Swiss Prot

P16035

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human TIMP-2(205-220aa RGAAPPKQEFLDIEDP), identical to the related rat and mouse sequences.

Scientific Background

TIMP2 gen is encoded by 5 exons spanning 83 kb of genomic DNA. TIMP2 is 83 kilobase pairs (kb) long with exon-intron splicing sites located in preserved positions among the three members of the TIMP family. The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25. TIMP-2 abrogates angiogenic factor-induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition.