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Products Polyclonal Anti-TGM1
| Catalogue number: | PA1956 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | TGM1 |
| Swiss prot: | P22735 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | TGM1(Transglutaminase1), also known as Transglutaminase, Epidermal Type I or TGK is an enzyme that in humans is encoded by the TGM1 gene. By fluorescence in situ hybridization, Yamanishi et al. (1992) mapped the TGM1 gene to 14q11.2.The TGM1 gene encodes transglutaminase-1, a catalytic membrane-bound enzyme that functions in the formation of the epidermal cornified cell envelope, which acts as a mechanical barrier to protect against water loss and infectious agents. |
| References: | 1. Farasat, S., Wei, M.-H., Herman, M., Liewehr, D. J., Steinberg, S. M., Bale, S. J., Fleckman, P., Toro, J. R. Novel transglutaminase-1 mutations and genotype-phenotype investigations of 104 patients with autosomal recessive congenital ichthyosis in the USA. J. Med. Genet. 46: 103-111, 2009. 2. Yamanishi, K., Inazawa, J., Liew, F.-M., Nonomura, K., Ariyama, T., Yasuno, H., Abe, T., Doi, H., Hirano, J., Fukushima, S. Structure of the gene for human transglutaminase 1. J. Biol. Chem. 267: 17858-17863, 1992. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human TGM1, identical to the related rat and mouse sequences. |
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