Quick Search
Products Polyclonal Anti-TFR2
| Catalogue number: | PA1901 |
| Price: | $200.00 |
| Reactivities: | Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | TFR2 |
| Swiss prot: | Q9JKX3 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | TFR2(Transferrin receptor protein 2), is a protein that in humans is encoded by the TFR2 gene. This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. By radiation hybrid analysis, Kawabata et al. (1999) mapped the TFR2 gene to chromosome 7q22.The majority of hepatic iron uptake under normal circumstances is transferrin-mediated. However, expression of TFRC in hepatocytes, as in other nonreticuloendothelial cell types, is downregulated in response to increased intracellular iron. As a consequence, TFRC expression in liver is undetectable in hereditary hemochromatosis patients with hepatic iron loading. Nonetheless, hepatic iron loading in hemochromatosis patients is progressive. Fleming et al. (2000) provided support for a mechanism that involves the uptake of transferrin-bound iron by TFR2. |
| References: | 1. Fleming, R. E., Migas, M. C., Holden, C. C., Waheed, A., Britton, R. S., Tomatsu, S., Bacon, B. R., Sly, W. S.Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis.Proc. Nat. Acad. Sci. 97: 2214-2219, 2000. 2. Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F., Koeffler, H. P.Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family.J. Biol. Chem. 274: 20826-20832, 1999. 3. Mattman, A., Huntsman, D., Lockitch, G., Langlois, S., Buskard, N., Ralston, D., Butterfield, Y., Rodrigues, P., Jones, S., Porto, G., Marra, M., De Sousa, M., Vatcher, G.Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation.Blood 100: 1075-1077, 2002. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of mouse TFR2, different from the related rat sequence by one amino acid. |
Get the Best Promotions
