Polyclonal Anti-TFPI

Rabbit IgG polyclonal antibody for Tissue factor pathway inhibitor (TFPI) detection. Tested with WB, IHC-P in Human. \n\n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1798

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

TFPI

References

1. Enjyoji, K.-I., Emi, M., Mukai, T., Imada, M., Leppert, M. L., Lalouel, J. M., Kato, H.Human tissue \nfactor pathway inhibitor (TFPI) gene: complete genomic structure and localization on the genetic map of \nchromosome 2q.Genomics 17: 423-428, 1993.\n2. Kleesiek, K., Schmidt, M., Gotting, C., Brinkmann, T., Prohaska, W.A first mutation in the human \ntissue factor pathway inhibitor gene encoding (P151L) TFPI. (Letter)Blood 92: 3976-3977, 1998.\n3. Lupu, C., Zhu, H., Popescu, N. I., Wren, J. D., Lupu, F.Novel protein ADTRP regulates TFPI \nexpression and function in human endothelial cells in normal conditions and in response to \nandrogen.Blood 118: 4463-4471, 2011.

Swiss Prot

P10646

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of \nhuman TFPI.

Scientific Background

TFPI(Tissue factor pathway inhibitor) also known as EPI, LACI, TFI and TFPT1 is a single-chain \npolypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, \nthe Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes \nsignificantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM. The \ngene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. TFPI has a \nrelative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal \nregion.\nREFERENCE