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Products Polyclonal Anti-TERT
| Catalogue number: | PA1696 |
| Price: | $200.00 |
| Reactivities: | Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | TERT |
| Swiss prot: | O70372 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | TERT(Telomerase reverse transcriptase), is a catalytic subunit of the enzyme telomerase. Its absence (usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat. The TERT gene was mapped to chromosome 5p15.33T by Meyerson, M. Elomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed the Hayflick limit and become potentially immortal, as is often the case with cancerous cells. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells, resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mice suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. |
| References: | 1.Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., Bacchetti, S., Haber, D. A., Weinberg, R. A.hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.Cell 90: 785-795, 1997. 2.Morales, C. P., Holt, S. E., Ouellette, M., Kaur, K. J., Yan, Y., Wilson, K. S., White, M. A., Wright, W. E., Shay, J. W.Absence of cancer-associated changes in human fibroblasts immortalized with telomerase.Nature Genet. 21: 115-118, 1999. 3.Oh, H., Taffet, G. E., Youker, K. A., Entman, M. L., Overbeck, P. A., Michael, L. H., Schneider, M. D.Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival.Proc. Nat. Acad. Sci. 98: 10308-10313, 2001. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of mouse TERT, identical to the related rat sequence. |
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