Polyclonal Anti-STK11/LKB1

Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase STK11 (STK11) detection. Tested with WB, IHC-P in Human;Mouse;Rat. \n

Prices direct from Boster Immunoleader

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1355

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

STK11

References

1.Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, M

Swiss Prot

Q15831

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human STK11, different from the mouse sequence by one amino acid.

Scientific Background

Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor Smith et al. (1999) found that the mouse Lkb1 gene encodes a protein showing strong sequence similarity to human LKB1. Karuman et al. (2001) demonstrated that LKB1 physically associates with p53 (191170) and regulates specific p53-dependent apoptosis pathways. Jenne et al. (1998) determined that the STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction. Smith et al. (1999) found that the mouse Lkb1 gene consists of 10 exons covering approximately 15 kb.