Polyclonal Anti-SOD2

Rabbit IgG polyclonal antibody for Superoxide dismutase [Mn], mitochondrial (SOD2) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat. \n\n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1776

Size

100ug/vial

Applications

ICC, IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

SOD2

References

1. Bastaki, M., Huen, K., Manzanillo, P., Chande, N., Chen, C., Balmes, J. R., Tager, I. B., Holland, \nN. Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and \ncatalase in humans. Pharmacogenet. Genomics 16: 279-286, 2006.\n2. Creagan, R., Tischfield, J., Ricciuti, F., Ruddle, F. H. Chromosome assignments of genes in man \nusing mouse-human somatic cell hybrids: mitochondrial superoxide dismutase (indophenol \noxidase-B, tetrameric) to chromosome 6. Humangenetik 20: 203-209, 1973.\n3. Hiroi, S., Harada, H., Nishi, H., Satoh, M., Nagai, R., Kimura, A. Polymorphisms in the SOD2 and \nHLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in \nJapanese. Biochem. Biophys. Res. Commun. 261: 332-339, 1999.

Swiss Prot

P04179

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of \nhuman SOD2,identical to the related mouse sequence and different \nfrom the related rat sequence by one amino acid .

Scientific Background

SOD2(Superoxide Dismutase 2), also called IPO-B or MNSOD, is a mitochondrial matrix enzyme that \nscavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport \nreactions occurring in mitochondria. This gene is a member of the iron/manganese superoxide \ndismutase family. Using a somatic cell hybrid panel containing different segments of chromosome 6, \nthey demonstrated that SOD2 is located in the region 6q25.3-qter which, together with the FISH \nanalysis, indicated that SOD2 is in the distal portion of 6q25. The SOD2 gene encodes an \nintramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide \nproduced as a byproduct of oxidative phosphorylation. Adeno-associated viral delivery of the \nhuman SOD2 gene resulted in suppression of optic nerve degeneration and rescue of retinal ganglion \ncells. The findings suggested that reactive oxygen species contributed to retinal cell death and optic \nnerve damage in mice with complex I deficiency, and that expression of SOD2 attenuated the disease \nprocess.