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Products Polyclonal Anti-SLC6A4
| Catalogue number: | PA1706 |
| Price: | $200.00 |
| Reactivities: | Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | SLC6A4 |
| Swiss prot: | P31652 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | SLC6A4(Solute carrier family 6, member 4), also known as SERT(serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma. |
| References: | 1.Kim, S.-J., Cox, N., Courchesne, R., Lord, C., Corsello, C., Akshoomoff, N., Guter, S., Leventhal, B. L., Courchesne, E., Cook, E. H., Jr.Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder.Molec. Psychiat. 7: 278-288, 2002. 2.Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., Murphy, D. L.Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.Science 274: 1527-1530, 1996. 3.Shen, S., Battersby, S., Weaver, M., Clark, E., Stephens, K., Harmar, A. J.Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes.Europ. J. Hum. Genet. 8: 75-78, 2000. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of rat SLC6A4, different from the related mouse sequence by one amino acid. |
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