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Products Polyclonal Anti-SLC30A4
| Catalogue number: | PA2191 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100?g/vial |
| Gene: | SLC30A4 |
| Swiss prot: | O14863 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Zinc transporter 4, also called SLC30A4 or ZNT4 is a protein that in humans is encoded by the SLC30A4 gene. SLC30A4, or ZNT4 belongs to the ZNT family of zinc transporters. This gene is mapped to 15q21.1. Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases, alkaline phosphatases, various dehydrogenases, and superoxide dismutases. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop. |
| References: | 1. Huang, L., Kirschke, C. P., Gitschier, J. Functional characterization of a novel mammalian zinc transporter, ZnT6. J. Biol. Chem. 277: 26389-26395, 2002. 2. Seve, M., Chimienti, F., Devergnas, S., Favier, A. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. BMC Genomics 5: 32, 2004. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminus of human SLC30A4, different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids. |
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