Polyclonal Anti-SLC2A12

Price

200.00 USD

Size

100?g/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Linden, K. C., DeHaan, C. L., Zhang, Y., Glowacka, S., Cox, A. J., Kelly, D. J., Rogers, S.Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. Am. J. Physiol. Renal Physiol. 290: F205-F213, 2006. \n2. Wood, I. S., Hunter, L., Trayhurn, P. Expression of class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues. Biochem. Biophys. Res. Commun. 308: 43-49, 2003. \n

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

Solute carrier family 2, facilitated glucose transporter member 12, also known as SLC2A12, is a protein that in humans is encoded by the SLC2A12 gene. SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion. This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues. By genomic sequence analysis, this gene is mapped to chromosome 6q23.2. SLC2A12 was detected in a perinuclear location in MCF7 cells in the absence of insulin; however, SLC2A12 redistributed to the plasma membrane of MCF7 cells grown continuously in the presence of insulin. This gene acts as facilitative glucose transporter.