Polyclonal Anti-SDC2

Rabbit IgG polyclonal antibody for Syndecan-2 (SDC2) detection. Tested with WB, IHC-P in Human.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1896

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

SDC2

References

1. Bobardt, M. D., Saphire, A. C. S., Hung, H.-C., Yu, X., Van der Schueren, B., Zhang, Z., David, G., Gallay, P. A.Syndecan captures, protects, and transmits HIV to T lymphocytes.Immunity 18: 27-39, 2003.\n2. David, G., van der Schueren, B., Marynen, P., Cassiman, J.-J., van den Berghe, H.Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells.J. Cell Biol. 118: 961-969, 1992.\n3. Marynen, P., Zhang, J., Cassiman, J.-J., Van den Berghe, H., David, G.Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts: prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts.J. Biol. Chem. 264: 7017-7024, 1989.\n

Swiss Prot

P34741

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence in the middle region of human SDC2.

Scientific Background

SDC2 (Syndecan-2) also known as SYND2, HSPG1, HSPG, and Fibroglycan, is a protein that in humans is encoded by the SDC2 gene. The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. By Southern hybridization to a panel of human-mouse somatic cell hybrid DNA and by in situ hybridization, Marynen et al. (1989) showed that the heparan sulfate proteoglycan core protein maps to 8q22-q24. (Heparan sulfate proteoglycan of basement membrane appears to be encoded by a gene on human chromosome 1.Bobardt et al. (2003) demonstrated that syndecans, including SDC2, can function as in trans HIV receptors via binding of HIV-1 gp120 to the syndecan heparan sulfate chains. Flow cytometric analysis demonstrated SDC expression on endothelial cells. HIV bound to SDC on endothelial cell lines maintained its infectivity for at least 1 week, compared with less than 1 day for unbound virus. Bobardt et al. (2003) suggested that SDC-rich endothelial cells lining the vasculature can provide a microenvironment that boosts HIV replication in T cells.