Polyclonal Anti-rm.CD80

Rabbit IgG polyclonal antibody for T-lymphocyte activation antigen CD80 (CD80) detection. Tested with WB in Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1365-1

Size

100ug/vial

Applications

WB

Reactivities

Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

CD80

References

1. Peach, R J; Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley P S (Sep. 1995). \"Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28\". J. Biol. Chem. (UNITED STATES) 270 (36): 21181

Swiss Prot

O55202

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of rat CD80, different from the related mouse sequence by two amino acids.

Scientific Background

Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al. (1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.