Quick Search
Products Polyclonal Anti-PTGER1
| Catalogue number: | PA1583 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | PTGER1 |
| Swiss prot: | P34995 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | PTGER1, Prostaglandin E Receptor 1, comprises 402 amino acids with a predicted molecular mass of 41,858 and has the 7 predicted transmembrane-spanning domains common to all G protein-coupled receptors. The PTGER1 gene is mapped to chromosome 19p13.1. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, Gq proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. |
| References: | 1.Funk, C. D., Furci, L., FitzGerald, G. A., Grygorczyk, R., Rochette, C., Bayne, M. A., Abramovitz, M., Adam, M., Metters, K. M.Cloning and expression of a cDNA for the human prostaglandin E receptor EP-1 subtype.J. Biol. Chem. 268: 26767-26772, 1993. 2.Matsuoka, Y., Furuyashiki, T., Yamada, K., Nagai, T., Bito, H., Tanaka, Y., Kitaoka, S., Ushikubi, F., Nabeshima, T., Narumiya, S.Prostaglandin E receptor E1 controls impulsive behavior under stress.Proc. Nat. Acad. Sci. 102: 16066-16071, 2005 3.Stock, J. L., Shinjo, K., Burkhardt, J., Roach, M., Taniguchi, K., Ishikawa, T., Kim, H.-S., Flannery, P. J., Coffman, T. M., McNeish, J. D., Audoly, L. P.The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.J. Clin. Invest. 107: 325-331, 2001. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human PTGER1 |
Get the Best Promotions
