Polyclonal Anti-PRNP

Price

200.00 USD

Size

100ug/vial

Reactivities

Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Bounhar, Y., Zhang, Y., Goodyer, C. G., LeBlanc, A.Prion protein protects human neurons against \nBax-mediated apoptosis.J. Biol. Chem. 276: 39145-39149, 2001.\n2. Brown, P., Galvez, S., Goldfarb, L. G., Nieto, A., Cartier, L., Gibbs, C. J., Jr., Gajdusek, D. C.Familial \nCreutzfeldt-Jakob disease in Chile is associated with the codon 200 mutation of the PRNP amyloid \nprecursor gene on chromosome 20.J. Neurol. Sci. 112: 65-67, 1992.\n3. Puckett, C., Concannon, P., Casey, C., Hood, L.Genomic structure of the human prion protein \ngene.Am. J. Hum. Genet. 49: 320-329, 1991.

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

PRNP(prion protein), also known as CD230 and PRP, is a protein that in humans is encoded by the \nPRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is \nmost predominant in the nervous system but occurs in many other tissues throughout the body. Puckett \net al. (1991)identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP \ngene, which might serve as a useful marker for the pter-p12 region of chromosome 20.PRNP is \nassociated with a variety of cognitive deficiencies and neurodegenerative diseases such as \nCreutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. PRNP is highly conserved \nthrough mammals, lending credence to application of conclusions from test animals such as mice.\nComparison between primates is especially similar, ranging from 92.9-99.6% similarity in amino acid \nsequences.