Polyclonal Anti-PPIB

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Peddada, L. B., McPherson, J. D., Law, R., Wasmuth, J. J., Youderian, P., Deans, R. J.Somatic cell mapping of the human Cyclophilin B gene (PPIB) to chromosome 15.Cytogenet. Cell Genet. 60: 219-221, 1992.\n2. Price, E. R., Zydowsky, L. D., Jin, M., Baker, C. H., McKeon, F. D., Walsh, C. T.Human Cyclophilin B: a second Cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.Proc. Nat. Acad. Sci. 88: 1903-1907, 1991.\n3. Watashi, K., Ishii, N., Hijikata, M., Inoue, D., Murata, T., Miyanari, Y., Shimotohno, K.Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.Molec. Cell 19: 111-122, 2005.\n

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Scientific Background

Cyclophilin B, PPIB, Peptidyl-prolyl cis-trans isomerase B, is an enzyme that in humans is encoded by the PPIB gene. Cyclophilins, such as Cyclophilin B, bind the immunosuppressive drug cyclosporin A (CsA) with high affinity. Somatic cell mapping of the human Cyclophilin B gene (PPIB) to chromosome 15. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.Cyclophilin B interacts with HCV RNA polymerase NS5B to directly stimulate its RNA binding activity.