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Products Polyclonal Anti-PPIB
| Catalogue number: | PA1448 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | PPIB |
| Swiss prot: | P23284 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Cyclophilin B, PPIB, Peptidyl-prolyl cis-trans isomerase B, is an enzyme that in humans is encoded by the PPIB gene. Cyclophilins, such as Cyclophilin B, bind the immunosuppressive drug cyclosporin A (CsA) with high affinity. Somatic cell mapping of the human Cyclophilin B gene (PPIB) to chromosome 15. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.Cyclophilin B interacts with HCV RNA polymerase NS5B to directly stimulate its RNA binding activity. |
| References: | 1. Peddada, L. B., McPherson, J. D., Law, R., Wasmuth, J. J., Youderian, P., Deans, R. J.Somatic cell mapping of the human Cyclophilin B gene (PPIB) to chromosome 15.Cytogenet. Cell Genet. 60: 219-221, 1992. 2. Price, E. R., Zydowsky, L. D., Jin, M., Baker, C. H., McKeon, F. D., Walsh, C. T.Human Cyclophilin B: a second Cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.Proc. Nat. Acad. Sci. 88: 1903-1907, 1991. 3. Watashi, K., Ishii, N., Hijikata, M., Inoue, D., Murata, T., Miyanari, Y., Shimotohno, K.Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.Molec. Cell 19: 111-122, 2005. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human PPIB, identical to the related mouse and rat sequence. |
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