Home  >  Products  >  Polyclonal Anti-PPIA
Polyclonal Anti-PPIA

Polyclonal Anti-PPIA

Cat no: PA1447

Supplier: Boster Immunoleader
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Rabbit IgG polyclonal antibody for Peptidyl-prolyl cis-trans isomerase A (PPIA) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Catalogue number: PA1447
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunohistochemistry, Western Blot
Size: 100ug/vial
Gene: PPIA
Swiss prot: P62937
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: Cyclophilin A?PPIA??Peptidylprolyl isomerase A?is an enzyme that in humans is encoded by the PPIA gene.Using chromosome 7 and chromosome 10 deletion hybrid panels, the PPIA coding gene is localized to 7p13-p11.2. This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. Cyclophilin A is a member of the immunophilin class of proteins that all possess peptidyl-prolyl cis/trans isomerase activity and are believed to be involved in protein folding and/or intracellular protein transport. Cyclophilin A binds to the Gag protein of human immunodeficiency virus type 1 (HIV-1). Cyclophilin A may have an essential function in HIV-1 replication.may have an essential function in HIV-1 replication.
References: 1. Luban, J., Bossolt, K. L., Franke, E. K., Kalpana, G. V., Goff, S. P.Human immunodeficiency virus type 1 gag protein binds to Cyclophilin A and B.Cell 73: 1067-1078, 1993. 2. Manel, N., Hogstad, B., Wang, Y., Levy, D. E., Unutmaz, D., Littman, D. R.A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.Nature 467: 214-217, 2010. Note: Erratum: Nature 470: 424 only, 2011. 3. Willenbrink, W., Halaschek, J., Schuffenhauer, S., Kunz, J., Steinkasserer, A. Cyclophilin A, the major intracellular receptor for the immunosuppressant cyclosporin A, maps to chromosome 7p11.2-p13: four pseudogenes map to chromosomes 3, 10, 14, and 18.Genomics 28: 101-104, 1995.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of human PPIA, different from the related mouse and rat sequence by one amino acid.
See Full Product Listings >