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Products Polyclonal Anti-PNPLA6
| Catalogue number: | PA1226 |
| Price: | $200.00 |
| Applications: | Immunohistochemistry, Immunohistochemistry - frozen, Western Blot |
| Size: | 100ug/vial |
| Gene: | PNPLA6 |
| Swiss prot: | F1R844 |
| Form: | Liquid |
| Format: | Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Patatin-like phospholipase domain containing 6 (PNPLA6), also known as Neuropathy target esterase (NTE), is a human gene. Neuropathy target esterase (NTE) is involved in neural development and is the target for neurodegeneration induced by selected organophosphorus pesticides and chemical warfare agents. The genetic or chemical reduction of Nte activity results in a neurological phenotype of hyperactivity in mammals and indicate that EOPF toxicity occurs directly through inhibition of Nte without the requirement for Nte gain of function or aging. |
| References: | 1. Winrow, C. J.; Hemming, M. L.; Allen, D. M.; Quistad, G. B.; Casida, J. E.; Barlow, C. : Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. Nature Genet. 33: 477-486, 2003. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of fish PNPLA6 |
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