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Products Polyclonal Anti-PIK3R2
| Catalogue number: | PA1680 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | PIK3R2 |
| Swiss prot: | O00459 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | PIK3R2(Phosphatidylinositol 3-kinase, regulatory subunit 2), also called p85-Beta, is an enzyme that in humans is encoded by the PIK3R2 gene. The PIK3R2 gene is mapped on 19p13.11. The NS1 protein from various influenza strains also bound p85-beta, but not p85-alpha. Binding of p85-beta and activation of PI3K required tyr89 of NS1, and mutant viruses expressing NS1 with a tyr89-to-phe substitution grew more slowly in cell culture than wildtype viruses. Using mouse embryonic fibroblasts, Park et al. showed that, in addition to regulating PI3K function, p85-alpha and p85-beta regulated the function of Xbp1s, a transcription factor that orchestrates the unfolded protein response (UPR) following endoplasmic reticulum (ER) stress. Overexpression of PIK3R2 in livers of ob/ob mice increased glucose tolerance and reduced blood glucose concentrations. |
| References: | 1.Hale, B. G., Jackson, D., Chen, Y.-H., Lamb, R. A., Randall, R. E. Influenza A virus NS1 protein binds p85-beta and activates phosphatidylinositol-3-kinase signaling. Proc. Nat. Acad. Sci. 103: 14194-14199, 2006. 2.Oak, J. S., Deane, J. A., Kharas, M. G., Luo, J., Lane, T. E., Cantley, L. C., Fruman, D. A. Sjogren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proc. Nat. Acad. Sci. 103: 16882-16887, 2006. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human PIK3R2, identical to the related rat and mouse sequences. |
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