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Products Polyclonal Anti-PER1
| Catalogue number: | PA2044 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | PER1 |
| Swiss prot: | O15534 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | PER1 (Period, Drosophila, Homolog of), also known as PER or RIGUI, is a protein that in humans is encoded by the PER1 gene. By fluorescence in situ hybridization, Sun et al. (1997) mapped the human PER1 gene to 17p12. Sun et al. (1997) found that in mouse retina, the expression of rigui oscillated over a 24-hour period, with highest expression at onset of dark in a 12-hour light/dark cycle, i.e., expression rose during the light period and fell during the dark period. RNA abundance of rigui changed 2.9-fold between highest and lowest levels in mouse retina. Shigeyoshi et al. (1997) examined the effects of light on rigui, designated mouse Per1 by them, which exhibits robust rhythmic expression in the SCN. They found that Per1 is rapidly induced by short duration exposure to light at levels sufficient to reset the clock. Von Gall et al. (2002) demonstrated that cycling expression of the clock gene Per1 in rodent pituitary cells depends on the heterologous sensitization of the adenosine A2B receptor, which occurs through the nocturnal activation of melatonin mt1 receptors. |
| References: | 1. Shigeyoshi, Y., Taguchi, K., Yamamoto, S., Takekida, S., Yan, L., Tei, H., Moriya, T., Shibata, S., Loros, J. J., Dunlap, J. C., Okamura, H. Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. Cell 91: 1043-1053, 1997. 2. Sun, Z. S., Albrecht, U., Zhuchenko, O., Bailey, J., Eichele, G., Lee, C. C. RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell 90: 1003-1011, 1997. 3. von Gall, C., Garabette, M. L., Kell, C. A., Frenzel, S., Dehghani, F., Schumm-Draeger, P.-M., Weaver, D. R., Korf, H.-W., Hastings, M. H., Stehle, J. H. Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin. Nature Neurosci. 5: 234-238, 2002. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of human PER1, identical to the related mouse sequence, and different from the related rat sequence by one amino acid. |
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