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Polyclonal Anti-PCSK4

Polyclonal Anti-PCSK4

Cat no: PA2086

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Proprotein convertase subtilisin/kexin type 4 (PCSK4) detection. Tested with WB in Mouse;Rat.
Catalogue number: PA2086
Price: $200.00
Reactivities: Mouse, Rat
Applications: Western Blot
Size: 100ug/vial
Gene: PCSK4
Swiss prot: P29121
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: PCSK4 (Proprotein Convertase, Subtilisin/Kexin-Type, 4), is an enzyme that in humans is encoded by the PCSK4 gene. The gene for PC4 (Pcsk4 locus) was mapped to mouse chromosome 10, close to the adipsin locus and near the gene encoding anti-mullerian hormone. Qiu et al. (2005) found that aberrant processing of pro-IGF2 by PC4 may be a cause of IUGR. PC4 cleaved pro-IGF2 to generate the intermediate processed form, IGF2 (1-102). Mature IGF2 (1-67), likely resulting from further processing by carboxypeptidases, is capable of activating invasive trophoblast cells through AKT phosphorylation. Inhibition of PC4 by a PC4-specific inhibitor blocked pro-IGF2 processing and reduced trophoblast cell migration.
References: 1. Cao, H., Mok, A., Miskie, B., Hegele, R. A. Single-nucleotide polymorphisms of the proprotein convertase subtilisin/kexin type 5 (PCSK5) gene. J. Hum. Genet. 46: 730-732, 2001. 2. Mbikay, M., Seidah, N. G., Chretien, M., Simpson, E. M. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. Genomics 26: 123-129, 1995. 3. Qiu, Q., Basak, A., Mbikay, M., Tsang, B. K., Gruslin, A. Role of pro-IGF-II processing by proprotein convertase 4 in human placental development. Proc. Nat. Acad. Sci. 102: 11047-11052, 2005.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of mouse PCSK4, different from the related rat sequence by one amino acid.
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