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Products Polyclonal Anti-P2X3
| Catalogue number: | PA1213 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | P2RX3 |
| Swiss prot: | P56373 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Purinergic receptor P2X, ligand-gated ion channel, 3, also known as P2X3, is a human gene. Its gene is mapped to 11q12. P2X purinoceptors are 397 to 492 amino acids long and have a predicted structure of 2 short intracellular domains, 2 transmembrane-spanning regions, and a large extracellular domain. The P2X3 subunit has 43% and 47% identity with P2X1 and P2X2, respectively; 10 cysteine residues are conserved in all 3 subtypes, so that tertiary structures may also be conserved. P2X3 was the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons. The remarkable selectivity of expression of the channel, coupled with a sensory neuron-like pharmacology, suggested that it may transduce ATP-evoked nociceptor activation. If ATP, and more specifically, P2X3 purinoceptors are involved in nociception, then the development of an antagonist selective for P2X3 could prove useful in pain relief. Lack of P2X3 in other tissues than sensory ganglia could afford a degree of specificity, leading to fewer side effects. |
| References: | 1. Kennedy, C.; Leff, P. : Painful connection for ATP. Nature 377: 385-386, 1995. 2. Chen, C.-C.; Akopian, A. N.; Sivilotti, L.; Colquhoun, D.; Burnstock, G.; Wood, J. N. : A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377: 428-430, 1995. 3. Kennedy, C.; Leff, P. : Painful connection for ATP. Nature 377: 385-386, 1995. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminus of human P2RX3, different from the related mouse and rat sequences by one amino acid. |
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