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Products Polyclonal Anti-P2RX7
| Catalogue number: | PA2129 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | P2RX7 |
| Swiss prot: | Q64663 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | P2X purinoceptor 7, also called P2X7, is a protein that in humans is encoded by the P2RX7 gene. The product of this gene belongs to the family of purnoceptors for ATP. P2RX7 was mapped to chromosome 12q24 by fluorescence in situ hybridization. It is a receptor for ATP that acts as a ligand-gated ion channel. This gene is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. It could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. |
| References: | 1. Adriouch, S., Dox, C., Welge, V., Seman, M., Koch-Nolte, F., Haag, F. Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor. J. Immun. 169: 4108-4112, 2002. 2. Cabrini, G., Falzoni, S., Forchap, S. L., Pellegatti, P., Balboni, A., Agostini, P., Cuneo, A., Castoldi, G., Baricordi, O. R., Di Virgilio, F. A his-155 to tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes. J. Immun. 175: 82-89, 2005. 3. Lemaire, I., Falzoni, S., Leduc, N., Zhang, B., Pellegatti, P., Adinolfi, E., Chiozzi, P., Di Virgilio, F. Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells. J. Immun. 177: 7257-7265, 2006. 4. Weber, F. C., Esser, P. R., Muller, T., Ganesan, J., Pellegatti, P., Simon, M. M., Zeiser, R., Idzko, M., Jakob, T., Martin, S. F. Lack of the purinergic receptor P2X (7) results in resistance to contact hypersensitivity. J. Exp. Med. 207: 2609-2619, 2010. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of rat P2RX7, different from the related mouse sequence by one amino acid, and from the related human sequence by two amino acids. |
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