Polyclonal Anti-NR5A1

Rabbit IgG polyclonal antibody for Steroidogenic factor 1 (NR5A1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2062

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

NR5A1

References

1. Jameson JL (2004). \"Of mice and men: The tale of steroidogenic factor-1.\". J. Clin. Endocrinol. Metab. 89 (12): 5927

Swiss Prot

Q13285

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human NR5A1, identical to the related rat and mouse sequences.

Scientific Background

NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1), also known as SF1 or FTZ1, is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR5A1 gene. By linkage analysis using interspecific backcross mice, Swift and Ashworth (1995) mapped the Nr5a1 gene to mouse chromosome 2. Shen et al. (1994) proposed that SF1 regulates MIS in vivo and participates directly in the process of mammalian sex determination. SF-1 is a critical regulator of reproduction, regulating the transcription of key genes involved in sexual development and reproduction. Its targets include genes at every level of the hypothalamic-pituitary-gonadal axis, as well as many genes involved in gonadal and adrenal steroidogenesis.