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Products Polyclonal Anti-NPY1R
| Catalogue number: | PA1130 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | NPY1R |
| Swiss prot: | P25929 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | NPY1R, Neuropeptide Y receptor Y1, is a protein that in humans is encoded by the NPY1R gene. NPY receptor is a member of the G protein-coupled receptor superfamily. The NPY Y1 receptor gene has 3 exons. By high resolution fluorescence in situ hybridization, the NPY1R gene is localized to chromosome 4q31.3-q32. NPY is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle. |
| References: | 1. Cavadas, C., Cefai, D., Rosmaninho-Salgado, J., Vieria-Coelho, M. A., Moura, E., Busso, N., Pedrazzini, T., Grand, D., Rotman, S., Waeber, B., Aubert, J.-F., Grousmann, E.Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion.Proc. Nat. Acad. Sci. 103: 10497-10502, 2006.2. 2. Herzog, H., Baumgartner, M., Vivero, C., Selbie, L. A., Auer, B., Shine, J.Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor.J. Biol. Chem. 268: 6703-6707, 1993. 3. Herzog, H., Hort, Y. J., Ball, H. J., Hayes, G., Shine, J., Selbie, L. A.Cloned human neuropeptide Y receptor couples to two different second messenger systems.Proc. Nat. Acad. Sci. 89: 5794-5798, 1992. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human NPY1R, identical to the related rat and mouse sequence. |
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