Polyclonal Anti-NOTCH1

Rabbit IgG polyclonal antibody for Neurogenic locus notch homolog protein 1 (NOTCH1) detection. Tested with WB in Human. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1215

Size

100ug/vial

Applications

WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

NOTCH1

References

1. Conlon, R. A.; Reaume, A. G.; Rossant, J. : Notch1 is required for the coordinate segmentation of somites. Development 121: 1533-1545, 1995. \n2. Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T (January 2001). \"Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate\". Neuron 29 (1): 45

Swiss Prot

P46531

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the middle region of human NOTCH1.

Scientific Background

Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.