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Polyclonal Anti-NOGO-A

Polyclonal Anti-NOGO-A

Cat no: PA1060

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Reticulon-4 (RTN4) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Catalogue number: PA1060
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunohistochemistry, Western Blot
Size: 100ug/vial
Gene: RTN4
Swiss prot: Q9NQC3
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: Human neurite outgrowth inhibitor (NOGO) cDNAs encodes 3 splice variants: NOGOA, NOGOB and NOGOC. The longest cDNA, designated NOGOA, has an open reading frame of 1192 amino acids. It is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity. Nogo-A, a member of the Reticulon family, is expressed by oligodendrocytes and associates primarily with the endoplasmic reticulum. The acidic amino terminus of Nogo-A is detected at the cytosolic face of cellular membranes and may contribute to inhibition of axon regeneration at sites of oligodendrocyte injury. A multivalent form of the N terminus of Nogo-A affects the morphology of both neurons and other cell types.
References: 1. Prinjha R, Moore SE, Vinson M, Blake S, Morrow R, Christie G, Michalovich D, Simmons DL, Walsh FS.Inhibitor of neurite outgrowth in humans. Nature. 2000 Jan 27; 403(6768):383-4. 2. Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME.Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature. 2000 Jan 27; 403(6768):434-9. 3. GrandPre T, Nakamura F, Vartanian T, Strittmatter SM.Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature. 2000 Jan 27; 403(6768):439-44. 4. Fournier AE, GrandPre T, Strittmatter SM. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001 Jan 18; 409(6818):341-6.
Additional info: A synthetic peptide corresponding to a sequence at the C-terminal of human Nogo-A, different from the related rat sequence by two amino acids, and from the related mouse sequence by one amino acid.
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