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Products Polyclonal Anti-MTA1
| Catalogue number: | PA1483 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Immunohistochemistry - frozen, Western Blot |
| Size: | 100ug/vial |
| Gene: | MTA1 |
| Swiss prot: | Q13330 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues.By fluorescence in situ hybridization, mapped the MTA1gene to chromosome 14q32.3. MTA1 is a component of the chromatin remodeling complex that influences gene transcription by modulating target gene chromatin. MTA1 is widely upregulated in many carcinomas. |
| References: | 1. Cui, Q., Takiguchi, S., Matsusue, K., Toh, Y., Yoshida, M. A.Assignment of the human metastasis-associated gene 1 (MTA1) to human chromosome band 14q32.3 by fluorescence in situ hybridization.Cytogenet. Cell Genet. 93: 139-140, 2001. 2. Reddy, S. D. N., Pakala, S. B., Ohshiro, K., Rayala, S. K., Kumar, R.MicroRNA-661, a c/EBP-alpha target, inhibits metastatic tumor antigen 1 and regulates its functions.Cancer Res. 69: 5639-5642, 2009. 3. Zhang, X., DeSalle, L. M., Patel, J. H., Capobianco, A. J., Yu, D., Thomas-Tikhonenko, A., McMahon, S. B.Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein.Proc. Nat. Acad. Sci. 102: 13968-13973, 2005. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human MTA1, identical to the related mouse and rat sequences. |
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