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Products Polyclonal Anti-MMP7
| Catalogue number: | PA1471 |
| Price: | $200.00 |
| Reactivities: | Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | MMP7 |
| Swiss prot: | Q10738 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | MMP7,matrix metalloproteinase-7, is an enzyme that in humans is encoded by the MMP7 gene. The MMP7 protein has 267 amino acids and is significantly shorter than stromelysin or collagenase. By Southern and PCR analysis of 2 different panels of somatic cell hybrids and by isotopic in situ hybridization, the MMP7 gene is mapped to 11q21-q22. It is a member of matrix metalloproteinase family. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. |
| References: | 1. Crawford, H. C., Scoggins, C. R., Washington, M. K., Matrisian, L. M., Leach, S. D.Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas.J. Clin. Invest. 109: 1437-1444, 2002. 2. Knox, J. D., Boreham, D. R., Walker, J.-A., Morrison, D. P., Matrisian, L. M., Nagle, R. B., Bowden, G. T.Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-q22.Cytogenet. Cell Genet. 72: 179-182, 1996. 3. Muller, D., Quantin, B., Gesnel, M.-C., Millon-Collard, R., Abecassis, J., Breathnach, R.The collagenase gene family in humans consists of at least four members.Biochem. J. 253: 187-192, 1988. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of mouse MMP7, different from the related rat sequence by two amino acids. |
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