Polyclonal Anti-MCM7

Rabbit IgG polyclonal antibody for DNA replication licensing factor MCM7 (MCM7) detection. Tested with WB, IHC-P, ICC in Human. \n\n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1792

Size

100ug/vial

Applications

ICC, IHC, WB

Reactivities

Hum

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

MCM7

References

1. Groth, A., Corpet, A., Cook, A. J. L., Roche, D., Bartek, J., Lukas, J., Almouzni, G. Regulation of \nreplication fork progression through histone supply and demand. Science 318: 1928-1931, 2007.\n2. Nakatsuru, S., Sudo, K., Nakamura, Y. Isolation and mapping of a human gene (MCM2) encoding a \nproduct homologous to yeast proteins involved in DNA replication.Cytogenet. Cell Genet. 68: \n226-230, 1995.\n3. Petrocca, F., Visone, R., Onelli, M. R., Shah, M. H., Nicoloso, M. S., de Martino, I., Iliopoulos, D., \nPilozzi, E., Liu, C.-G., Negrini, M., Cavazzini, L., Volinia, S., Alder, H., Ruco, L. P., Baldassarre, G., \nCroce, C. M., Vecchione, A. E2F1-regulated microRNAs impair TGF-beta-dependent cell-cycle \narrest and apoptosis in gastric cancer. Cancer Cell 13: 272-286, 2008.

Swiss Prot

P33993

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of \nhuman MCM7.

Scientific Background

MCM7(Minichromosome Maintenance, s. Cerevisiae, homolog of, 7), also called CDC47, FORMERLY,\nis one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the \ninitiation of eukaryotic genome replication. The MCM7 gene is mapped on 7q22.1. MCM7 plays a \npivotal role in the G1/S phase transition, orchestrating the correct assembly of replication forks on \nchromosomal DNA and ensuring that all the genome is replicated once and not more than once at each \ncell cycle. The MCM7 gene contains 15 exons. The miRNAs MIR106B, MIR93, and MIR25 are \nclustered in a 5-prime to 3-prime orientation within intron 13. Petrocca et al. (2008) found \nthat MCM7 and the precursors of microRNAs (miRNAs) MIR106B, MIR93, and MIR25, all of which \narise from intron 13 of the MCM7gene, were overexpressed with almost perfect correlation in 5 of 10 \nhuman gastric tumors.