Polyclonal Anti-MCM6

Price

200.00 USD

Size

100ug/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Bersaglieri, T., Sabeti, P. C., Patterson, N., Vanderploeg, T., Schaffner, S. F., Drake, J. A., Rhodes, \nM., Reich, D. E., Hirschhorn, J. N. Genetic signatures of strong recent positive selection at the \nlactase gene. Am. J. Hum. Genet. 74: 1111-1120, 2004.\n2. Coelho, M., Luiselli, D., Bertorelle, G., Lopes, A. I., Seixas, S., Destro-Bisol, G., Rocha, \nJ. Microsatellite variation and evolution of human lactase persistence. Hum. Genet. 117: 329-339, \n2005.\n3. Enattah, N. S., Sahi, T., Savilahti, E., Terwilliger, J. D., Peltonen, L., Jarvela, I. Identification of a \nvariant associated with adult-type hypolactasia. Nature Genet. 30: 233-237, 2002.

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

MCM6(Minichromosome maintenance, s. pombe, homolog of, 6) is a protein that in humans is encoded \nby the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins \n(MCM) that are essential for the initiation of eukaryotic genome replication. The MCM genes were \noriginally identified in yeast defective in minichromosome maintenance and have since been shown to \nplay roles in the progression of the cell cycle; many are cell division control genes. The MCM6 gene is \nmapped on 2q21.3. Mcm 6 has recently been shown to interact strongly Cdt1 at defined residues, by \nmutating these target residues Wei et al. observed lack of Cdt1 recruitment of Mcm2-7 to the pre-RC.\nAn approximately 200-kb region surrounding the C/T(-13910) polymorphism in MCM6 intron 13 \nfunctioned as an enhancer of the lactase gene promoter in intestinal cell culture.