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Products Polyclonal Anti-LTK
| Catalogue number: | PA1990 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | LTK |
| Swiss prot: | P29376 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | LTK (Leukocyte Tyrosine Kinase), also known as TYK1, is an enzyme that in humans is encoded by the LTK gene. The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown. Toyoshima et al. (1993) cloned a set of cDNAs representing differently spliced human LTK mRNAs. Liao et al. (1996) found that the mouse Ltk gene is closely linked to the Tyro3 gene which maps to mouse chromosome 2. Thus, the LTK gene produces not only the putative receptor tyrosine kinase for an unknown ligand but also multiple protein products that may have different functions. |
| References: | 1. Li, N., Nakamura, K., Jiang, Y., Tsurui, H., Matsuoka, S., Abe, M., Ohtsuji, M., Nishimura, H., Kato, K., Kawai, T., Atsumi, T., Koike, T., Shirai, T., Ueno, H., Hirose, S. Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum. Molec. Genet. 13: 171-179, 2004. 2. Liao, X., Zhou, R., Gilbert, D. J., Copeland, N. G., Jenkins, N. A. Receptor tyrosine kinase gene Tyro3 maps to mouse chromosome 2, closely linked to Ltk. Mammalian Genome 7: 395-396, 1996. 3. Toyoshima, H., Kozutsumi, H., Maru, Y., Hagiwara, K., Furuya, A., Mioh, H., Hanai, N., Takaku, F., Yazaki, Y., Hirai, H. Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. Proc. Nat. Acad. Sci. 90: 5404-5408, 1993. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human LTK |
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