Polyclonal Anti-LAT

Price

200.00 USD

Size

100?g/vial

Reactivities

Hum

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References

1. Hundt, M., Tabata, H., Jeon, M.-S., Hayashi, K., Tanaka, Y., Krishna, R., De Giorgio, L., Liu, Y.-C., Fukata, M., Altman, A. Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. Immunity 24: 513-522, 2006.\n2. Nunez-Cruz, S., Aguado, E., Richelme, S., Chetaille, B., Mura, A.-M., Richelme, M., Pouyet, L., Jouvin-Marche, E., Xerri, L., Malissen, B., Malissen, M. LAT regulates gamma-delta T cell homeostasis and differentiation. Nature Immun. 4: 999-1008, 2003.\n

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

Linker for activation of T cells, also known as LAT, is a protein which in humans is encoded by the LAT gene. This gene is mapped to 16p11.2. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement.