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Products Polyclonal Anti-LAT
| Catalogue number: | PA2161 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Immunocytochemistry, Immunohistochemistry, Western Blot |
| Size: | 100?g/vial |
| Gene: | LAT |
| Swiss prot: | O43561 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Linker for activation of T cells, also known as LAT, is a protein which in humans is encoded by the LAT gene. This gene is mapped to 16p11.2. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. |
| References: | 1. Hundt, M., Tabata, H., Jeon, M.-S., Hayashi, K., Tanaka, Y., Krishna, R., De Giorgio, L., Liu, Y.-C., Fukata, M., Altman, A. Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. Immunity 24: 513-522, 2006. 2. Nunez-Cruz, S., Aguado, E., Richelme, S., Chetaille, B., Mura, A.-M., Richelme, M., Pouyet, L., Jouvin-Marche, E., Xerri, L., Malissen, B., Malissen, M. LAT regulates gamma-delta T cell homeostasis and differentiation. Nature Immun. 4: 999-1008, 2003. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human LAT, different from the related mouse and rat sequences by six amino acids. |
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