

Supplier:
Boster ImmunoleaderCat no: PA1047
Polyclonal Anti-KCA3.1
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SPECIFICATIONS
Price
200.00 USD
Catalog Number
PA1047
Size
100ug/vial
Applications
IHC, WB
Reactivities
Hum, Mouse, Rat
Form
Lyophilized
Format
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Gene Id
KCNN4
References
1. Joiner WJ, Wang LY, Tang MD, Kaczmarek LK. Joiner,W.J., Wang,L.Y., Tang,M.D. and Kaczmarek,L.K. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc. Natl. Acad. Sci. U.S.A.1997; 94 (20), 11013-11018.\n2. Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A. The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. Proc. Natl. Acad. Sci. U.S.A.2003; 100 (12), 7366-7371.\n3. Jones HM, Hamilton KL, Papworth GD, Syme CA, Watkins SC, Bradbury NA, Devor DC. Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. J. Biol. Chem.2004; 279 (15), 15531-15540.
Swiss Prot
O15554
Storage Temp
\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n
Additional Info
A synthetic peptide corresponding to a sequence at the N-terminal of human KCNN4 (11-28aa ALRRRKRLLEQEKSLAGW), different from the related rat and mouse sequences by two amino acids.
Scientific Background
Intermediate conductance calcium-activated potassium channel protein 1 (KCNN4,Kca3.1) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
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