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Polyclonal Anti-ITGB2

Polyclonal Anti-ITGB2

Cat no: PA1124

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Integrin beta-2 (ITGB2) detection. Tested with WB, IHC-P in Human.
Catalogue number: PA1124
Price: $200.00
Reactivities: Human
Applications: Immunohistochemistry, Western Blot
Size: 100ug/vial
Gene: ITGB2
Swiss prot: P05107
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated CD18. The 3 alpha integrin chains associated individually with the beta-2 chain as a heterodimer have gene designations of ITGAL, ITGAM, and ITGAX, and leukocyte antigen designations of CD11A, CD11B, and CD11C, respectively.The expression of CD18 was increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21.The ITGB2 gene spans approximately 40 kb and contains 16 exons and all exon/intron boundaries conform to the GT/AG splicing consensus. Furthermore,ITGB2 was constitutively clustered. Although it was expressed on the cell surface at normal levels and was capable of function following extracellular stimulation, it could not be activated via the
References: 1. Taylor, G. M.; Williams, A.; D'Souza, S. W.; Fergusson, W. D.; Donnai, D.; Fennell, J.; Harris, R. : The expression of CD18 is increased on trisomy 21 (Down syndrome) lymphoblastoid cells. Clin. Exp. Immun. 71: 324-328, 1988. 2. Weitzman, J. B.; Wells, C. E.; Wright, A. H.; Clark, P. A.; Law, S. K. A. : The gene organisation of the human beta-2 integrin subunit (CD18). FEBS Lett. 294: 97-103, 1991. 3. McDowall, A.; Inwald, D.; Leitinger, B.; Jones, A.; Liesner, R.; Klein, N.; Hogg, N. : A novel form of integrin dysfunction involving beta-1, beta-2, and beta-3 integrins. J. Clin. Invest. 111: 51-60, 2003.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of human Integrin beta2, different from the related mouse sequence by five amino acids.
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